Gender‐related changes in increase of dopaminergic neurons in the olfactory bulb of Parkinson's disease patients
Identifieur interne : 002826 ( Main/Exploration ); précédent : 002825; suivant : 002827Gender‐related changes in increase of dopaminergic neurons in the olfactory bulb of Parkinson's disease patients
Auteurs : Evelien Huisman [Pays-Bas] ; Harry B. M. Uylings [Pays-Bas] ; Piet V. Hoogland [Pays-Bas, Afrique du Sud]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-07-30.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Cell Count, Dopamine, Dopamine (biosynthesis), Dopamine (physiology), Dopaminergic neuron, Female, Human, Humans, Male, Middle Aged, Nerve Tissue Proteins (analysis), Nervous system diseases, Neurons (enzymology), Neurons (pathology), Olfaction Disorders (etiology), Olfaction Disorders (pathology), Olfactory Bulb (chemistry), Olfactory Bulb (pathology), Olfactory bulb, Olfactory disorder, Parkinson Disease (complications), Parkinson Disease (pathology), Parkinson disease, Parkinson's, Sex, Sex Characteristics, Tyrosine 3-Monooxygenase (analysis), dopamine, gender difference, hyposmia, olfactory bulb.
- MESH :
- chemical , analysis : Nerve Tissue Proteins, Tyrosine 3-Monooxygenase.
- chemical , biosynthesis : Dopamine.
- chemical , physiology : Dopamine.
- chemistry : Olfactory Bulb.
- complications : Parkinson Disease.
- enzymology : Neurons.
- etiology : Olfaction Disorders.
- pathology : Neurons, Olfaction Disorders, Olfactory Bulb, Parkinson Disease.
- Aged, Aged, 80 and over, Cell Count, Female, Humans, Male, Middle Aged, Sex Characteristics.
Abstract
Gender differences in dopaminergic related neurodegenerative diseases have hardly been studied until now. It is generally accepted that more men than women suffer from Parkinson's disease. One of the most prevalent symptoms in Parkinson's patients, hyposmia, does not show gender differences, while normally the sense of smell is better developed in females. Whether the change in dopamine in the olfactory bulb contributes equally to hyposmia in male and female Parkinson's patients is the subject of the present study. In a stereological study the total number of tyrosine hydroxylase immunoreactive neurons in the olfactory bulbs of male and female Parkinson's patients and age‐matched controls has been estimated. The present stereological study shows that the number of tyrosine hydroxylase positive cells in control females is significantly lower than those in control males. The number of dopaminergic cells in the olfactory bulbs of both male and female Parkinson's patients equals that of healthy males of the same age group. We therefore conclude that the hyposmia in Parkinson's disease patients cannot simply be ascribed to dopamine in the olfactory bulb. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22009
Affiliations:
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Le document en format XML
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Hoogland</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Department of Anatomy and Histology, Faculty of Health Sciences, University of Stellenbosch</wicri:regionArea><wicri:noRegion>University of Stellenbosch</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-07-30">2008-07-30</date><biblScope unit="vol">23</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1407">1407</biblScope><biblScope unit="page" to="1413">1413</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">CB39143824957859D3A6BAF30E26C7BFA140BDD2</idno><idno type="DOI">10.1002/mds.22009</idno><idno type="ArticleID">MDS22009</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cell Count</term><term>Dopamine</term><term>Dopamine (biosynthesis)</term><term>Dopamine (physiology)</term><term>Dopaminergic neuron</term><term>Female</term><term>Human</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nerve Tissue Proteins (analysis)</term><term>Nervous system diseases</term><term>Neurons (enzymology)</term><term>Neurons (pathology)</term><term>Olfaction Disorders (etiology)</term><term>Olfaction Disorders (pathology)</term><term>Olfactory Bulb (chemistry)</term><term>Olfactory Bulb (pathology)</term><term>Olfactory bulb</term><term>Olfactory disorder</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (pathology)</term><term>Parkinson disease</term><term>Parkinson's</term><term>Sex</term><term>Sex Characteristics</term><term>Tyrosine 3-Monooxygenase (analysis)</term><term>dopamine</term><term>gender difference</term><term>hyposmia</term><term>olfactory bulb</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Nerve Tissue Proteins</term><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Olfactory Bulb</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Olfaction Disorders</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Neurons</term><term>Olfaction Disorders</term><term>Olfactory Bulb</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cell Count</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Sex Characteristics</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Bulbe olfactif</term><term>Dopamine</term><term>Homme</term><term>Maladie de Parkinson</term><term>Neurone dopaminergique</term><term>Pathologie du système nerveux</term><term>Sexe</term><term>Trouble de l'odorat</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Gender differences in dopaminergic related neurodegenerative diseases have hardly been studied until now. It is generally accepted that more men than women suffer from Parkinson's disease. One of the most prevalent symptoms in Parkinson's patients, hyposmia, does not show gender differences, while normally the sense of smell is better developed in females. Whether the change in dopamine in the olfactory bulb contributes equally to hyposmia in male and female Parkinson's patients is the subject of the present study. In a stereological study the total number of tyrosine hydroxylase immunoreactive neurons in the olfactory bulbs of male and female Parkinson's patients and age‐matched controls has been estimated. The present stereological study shows that the number of tyrosine hydroxylase positive cells in control females is significantly lower than those in control males. The number of dopaminergic cells in the olfactory bulbs of both male and female Parkinson's patients equals that of healthy males of the same age group. We therefore conclude that the hyposmia in Parkinson's disease patients cannot simply be ascribed to dopamine in the olfactory bulb. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Pays-Bas</li></country><region><li>Hollande-Septentrionale</li></region><settlement><li>Amsterdam</li></settlement></list><tree><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Huisman, Evelien" sort="Huisman, Evelien" uniqKey="Huisman E" first="Evelien" last="Huisman">Evelien Huisman</name></region><name sortKey="Hoogland, Piet V" sort="Hoogland, Piet V" uniqKey="Hoogland P" first="Piet V." last="Hoogland">Piet V. Hoogland</name><name sortKey="Uylings, Harry B M" sort="Uylings, Harry B M" uniqKey="Uylings H" first="Harry B. M." last="Uylings">Harry B. M. Uylings</name><name sortKey="Uylings, Harry B M" sort="Uylings, Harry B M" uniqKey="Uylings H" first="Harry B. M." last="Uylings">Harry B. M. Uylings</name></country><country name="Afrique du Sud"><noRegion><name sortKey="Hoogland, Piet V" sort="Hoogland, Piet V" uniqKey="Hoogland P" first="Piet V." last="Hoogland">Piet V. Hoogland</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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